His version of Somewhere Over The Rainbow is one of the prettiest songs I've heard on uke. Ukulele - Somewhere Over The Rainbow & Wonderful World - Ukulele Play Along Ukulaliens - Ukulele Club 137K subscribers Subscribe 2.4K 310K views 3 years ago Ukulele play along of. C Someday i'll wish upon a star G Am F Wake up where the clouds are far behind me C Where trouble melts like lemon drops G Am F High above the chimney tops that's where you'll find me C Em F C Oh somewhere over the rainbow, blue birds fly F C G Am F And the dreams that you dare to, oh why, oh why can't I. UPDATE: A very IZ-inspired ukulele version turned up on Glee last night.It's about time I put the chords up to this song, made famous on ukulele by the late great Israel Kamakawiwoʻole (Iz). Bloody Paula Abdul.Ī big thanks to Jeff for alerting me to this performance. After hearing this song I was inspired to learn it and challenged by my dad to perform it. Ive had a uke for a while but never sat down and actually learned a real song. One thing it’s definitely not is a guitar. Somewhere Over the Rainbow This is my ukulele recording debut and is a direct cover of Israel Kamakawiwooles version, made famous in the USA by the movie 50 First Dates. To answer Julie’s question it’s an Oscar Schmidt ukulele. The strumming pattern varies throughout the song, but good starting place is: Learn how to strum like IZ on the classic Somewhere Over The Rainbow in this ukulele tutorial. His version of the chords are simpler than Brudda IZ’s – particularly since the intro is missed off – which makes it ideal for beginners. Intro G Verse 1 G D C Somewhere over the rainbow, G way up high C G There’s a land that I’ve heard of D Em once in a lullaby C Ooooh Verse 2 G D C Somewhere over the rainbow, G skies are. Despite the obligatory American Idol warblings, I thought Jason Castro made a pretty good stab at the song. look like two goofy tourists, said Coby as he strummed on his fake ukulele. But, when I realised even Simon Cowell isn’t too hard-hearted and cynical to be won over by a song’s charm, I reconsidered my position. OFFICIAL Somewhere over the Rainbow - Israel 'IZ' Kamakawiwoole - YouTube 0:00 / 3:47 OFFICIAL Somewhere over the Rainbow - Israel 'IZ' Kamakawiwoole Mountain Apple Company Inc 1.53M. She hummed Somewhere over the Rainbow, a tune by Israel Kamakawiwo'le. I never thought I’d be putting this song on the blog. Jason Castro/Israel Kamakawiwo’ole – Somewhere Over the Rainbow (Click here for Chords)
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I run a GeForce GTX 1060 and an intel i5 7600K with 16GB of RAM, so my computer specs are fine, but i still don't know what's causing this problem in the game. but other times, i'll still have vsync on and all the same settings and it'll stutter a lot and vary between 45-55fps, making the game more difficult to play. The weird thing is, sometimes when i load up the game and play, i'll keep my vsync on and it'll stay at a constant 60fps no matter the settings. i also attempted messing around in the NVIDIA Control Panel, but no luck still. ever since i installed NVIDIAs last GeForce Game Ready driver, the framerate has been constantly stuttering even with vsync turned on and settings on low. i have tried rolling back the driver to a previous version but that hasn't worked either. ive been having problems with the framerate in this game and havent been able to fix it, even though ive spent hours trying. before i installed the driver i was able to run max settings at 120fps with little/no problems. So The Waypoint mode and Playground mode are made to make the game fun for both new and experienced players.I've been having problems with the framerate in this game and haven't been able to fix it, even though i've spent hours trying.Įver since i installed NVIDIA's last GeForce Game Ready driver, the framerate has been constantly stuttering even with vsync turned on and settings on low. The other one is Playground mode this mode is for newbies who have less experience of riding a bike and for those players who want to improve their riding abilities. In Waypoint mode, you can create your racing track with your barriers, blockades and strategies. There are several new modes which are integrated into this game to make the game fun to play like Waypoint mode. So the gameplay varies with modes, in single-player mode, the gameplay will be less challenging and less hard, but in multiplayer mode, it will give you a tough and more challenging time. MXGP 2020 Free Download: The Official Motocross videogame’s gameplay is fascinating, what can be more exciting than racing with a bike to become #1 player in the racing arena? This game is not yet released, but the developers of this game are planning to release it on 16 December 2020, and it will be available to play on following platforms: PlayStation4, Xbox One, Nintendo Switch and Microsoft Windows. The rider and racing bike of the brands will be different from each other and techniques, and strategies will also vary greatly. You can choose any brand from over 110 official brands. This game gives you full freedom of customisation of the rider and racing bike. The race, of course, will be challenging in single-player mode and more tough in multiplayer mode because you will play against real human beings. In this game, your task will be to race efficiently and take #1 position among other competitors whether you play in single-player mode or multiplayer mode. If you have a good internet connection, then the multiplayer mode is built for you. The servers of this game are very reliable with almost zero reaction time and have a considerable bandwidth. This game can be played in single-player mode alone and also in online amultiplayer mode against your friends also. It has a good history in racing sports category so you can expect a well-developed game. Milestone S.r.l is not a new studio in a racing sports game. MXGP 2020 Free Do: The Official Motocross videogame is a racing sports game developed by Milestone S.r.l and published by the same studio. Which software should you choose for creating a collage that you’ll love? Each of the programs we discussed in this article has its strengths and weaknesses, depending on the type of collage you want to make. Change the background color(s), and make any adjustments you want.Ĭlick on the gray Download button at the top right corner to save your collage, or you can click on Share to publish it or save it to Google Drive. (Optional) Add any other effects, features, and/or text that you like. After this, you can select all of the photos and group them to keep them in the same configuration. Repeat this step with all of the photos in the collage. If you don’t see one you love, try typing in a related keyword or key phrase in the search box.Ĭlick on the stock photos in the template and click on Ungroup in the menu bar that pops up on the right.Ĭlick on one of the images and click the Replace button to upload your photo. Once you log in, it will take you directly to Adobe® Express to create your collage.Ĭhoose a template from the designs on the left. Follow the steps above on how to make a photo collage, then share it on your social media profiles, and make your audience drool.Click on the dark blue Design your free collage now button.Ĭreate a free Adobe® Cloud account, or use your existing account to log in. Share recipesĪ photo collage with tasty looking meals can be the first step towards getting more traffic to your website. 10 Creative photo collage ideas to use in 2023 1. Now that you know how to make a collage of photos let’s see a few ways to use them along with inspiring templates to start from. Remember that you can create your collage from scratch and get creative when it comes to all the features you have at your disposal. You can always come back, make changes, and re-export your design. Download the photo collageĪfter you added the finishing touches and your photo collage is ready, it’s time to download it in JPG or PNG format. Choose a mask that fits your photo collage theme and then just upload an image from your computer or use one from our stock gallery. Last but not least, feel free to delete images from the collage and replace them with clipping mask s to make it stand out even more. You can get even more creative by adding different design elements, such as geometric shapes, lines, icons, or illustrations, all of which you can find in the Elements section. In case you want to change the aesthetic of your photo collage, you can add a background, play with filters, or the opacity and blur levels. You can not only edit the text, but you can also change the font, the size, or its color. The templates come with their own text, so feel free to change it. Now it’s time to really dig in and make good use of Creatopy’s features. Edit the text, add a background, filters, or other graphic elements You can replace every photo from any template and personalize it to create a unique visual while keeping the format and grid style. To do that, just select the image you want to replace, click the Settings icon, and then on Replace from My Computer.Īdditionally, you can choose photos from our stock gallery and use the drag and drop option to add the images you like in the photo collage. Once you’ve picked your favorite template, it’s time to add your personal touch by uploading your photos. Keep in mind that you can replace all the images from a template, so if you like one that’s not designed for your industry, you can use it anyway and personalize it to your liking. Or you can simply scroll down until you find a photo collage template you like and then click on it to go to the editor. The templates are divided into a few categories so you can browse through them to find a template that suits your industry and needs. Choose a photo collage templateĪfter you log into your account (or create one), go to Start creating, type in “photo collage”, and click on this size.Īfter you do that, you’ll see all the templates that are available for photo collages. How to Make a Photo Collage with CreatopyĪll the tools you need to create a collage are in Creatopy, so keep reading to learn how to make photo collages that your audience will love. Now I’m going to show you how to create and customize these types of designs in Creatopy, in just a few simple steps. Whether you want to present your products or services in a unique way or do something different for your social media profiles, photo collages are the answer. Your brand’s unique story or personal memories take a creative shape when you bring visuals together. Imagine how much more you’re able to capture by creating a photo collage. It can express emotion and tell a story without needing any other words. No one can argue with the power of visual content. 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The CPM user has the authorization to retrieve the fileĬheck that the user that runs the CPM has permission to delete files from the temp directory.ĬACPM084I Refreshing Session (New session ID: ).ĬACPM085I Encountered a disconnected Session.ĬACPM087E Error initilizing PrivateArk object (error: ).ĬACPM089I Backup password/s found in workspace Safe (backup password name>,).ĬACPM090I Checking login with backup password. The password can be changed within the timeout specified.Ĭheck that the value is a valid XML value.ĬACPM077E Failed to locate vault categories.Ĭheck that the ‘PolicyID’ and ‘InProcess’ File Categories exist in the Vault.ĬACPM079I Starting Central Policy Manager.ĬACPM081E User's safe was not found (error: ).ĬACPM082E Error retrieving file (error: ). The remote resource can be reached within the timeout specified Timeout () elapsed (Safe:, Folder:, Object: ). The information in the password object is correctĬACPM073E Change password process terminated. In the policy file, specify the name of the component that is responsible for the password change.ĬACPM071E Error creating change password process (error ).ĬACPM072E process on remote machine failed (error:, Safe:, Folder: s, Object: ). No action is required.ĬACPM070E Invalid policy parameters - no change password component specified. Make sure that the password length does not exceed 170 characters. ĬACPM067E Error encrypting password - check password policy parameters. Ĭheck that the CPM user has the authorization to store the log file in the Safe and that the Safe has enough empty space.ĬACPM065E Error decrypting backup password. Ĭheck that the mandatory field specified in the error message appears in the specified file.Ĭheck that the Safe can be opened by the CPM user.ĬACPM062E Error storing log file to Safe. The CPM user can retrieve the specified file.ĬACPM060E Error reading mandatory field from file. The specified file exists in the specified Safe Ĭheck that the file specified in the error message is a valid ini file.ĬACPM058E Parameter file was not found in Safe. Make sure the definition file in the CPM Vault directory is valid.ĬACPM020E Could not get host name (code ).ĬACPM026E Could not initialize logger (code ).Ĭheck that the user that is used to run the CPM has permission to create/modify/read files in the logs directory and that this user can create the logs directory in case it doesn’t exist.ĬACPM027E Could not send failure notification email (error ).Ĭheck that the email details you supplied are valid.ĬACPM031E Could not change directory to (code ).Ĭheck that the directory specified in the error message exists and that the user that runs the CPM has permission to access the directory.ĬACPM036E Could not open registry path (code ).Ĭheck that the registry key specified in the error message exists and that the user that runs the CPM has permission to access it.ĬACPM037E Could not open query path (code ).ĬACPM038E Could not create temporary log directory (code ).Ĭheck that the user that runs the CPM has permission to create the directory specified in the error message.ĬACPM045E Error creating instance of Session Manager.ĬACPM046E Error getting Session from Session Manager (Vault name:).ĬACPM047E Error getting duplicated Session from Session Manager (Vault name:, User name: ).ĬACPM048E Error getting vault from Session (error: ).ĬACPM049E Error getting Safe from vault (error: ).ĬACPM051E Error getting folder from Safe (error: ).Ĭheck that the Root and Policies folders in the CPM user’s Safe are valid and can be accessed.ĬACPM052E Error getting files in folder (error: ).Ĭheck that the files in the Policies folder in the CPM user’s Safe are valid and can be retrieved.Ĭheck that the user that runs the CPM has permission to create, delete, and add files in the logs directory.ĬACPM055E Error initializing Error Notify service.ĬACPM056E Could not create temporary directory (code ).ĬACPM057E Failed to read parameter file. ĬACPM004E Could not read vault definition file. Ĭheck that the user name, password and vault configurations are valid.ĬACPM003E Invalid command line parameters. CACPM001E Session of user has been disconnected from vault. Many have been waiting for this: lines, circles and rectangles can now be created as vector objects, optionally with a shadow.Just like on iPhones and iPads, you can now automatically crop people and objects and insert them into another image, for example.This means that there is no loss of quality with compressed formats such as JPG and HEIC, and RAW images can also be edited. Your advantage: You can, for example, delete parts of the metadata such as exposure time and aperture in one editing step and copy the contents of an IPTC field into another field, etc. With the new Metadata Juggler dialog you can effortlessly combine several editing steps, save them and open them again at any time, just as you already know from the actions. With GraphicConverter you have always been able to edit the metadata of your images and move them to other fields.The result is an effect that enchants your pictures.ĭo you organize your work with Finder Tags from Apple? Then your work will be even easier, because in the browser you can now use the context menu to directly display and change these tags. In this impressive technique, the lighter shades are colored with the color 1 and the darker ones with the color 2. Easily create color gradients with up to 10 colors via the new dialog.Ĭolor your shots with two colors to duo-tone images. as a background for a collage? No problem. With the new wide-angle equalization in GraphicConverter 11, you can now reduce this distortion. In wide-angle shooting, faces and objects on the left and right edges of the image are often heavily distorted in width. In addition to the Zip format, there are 12 additional formats supported, such as the TAR and TGZ formats. 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TIF, TIFF, WBMP, WMF, EMF, PNG, TGA, and more. and supports saving graphics to BMP, GIF, JPG, JPEG, ICO, DIB, It supports reading graphics ofīMP, DIB, JPG, JPEG, GIF, ICO, ICB, PCX, PCD, PSP, PBM, PGM, PSD, PPM, PSG, PNG, VST, VDA, EMF, WMF, It supports more thanĥ0 different filters. You may choose Easy Graphic Converter, a very small image processing software for Windows with powerful functions.Įasy Graphic Converter is an all-in-one batch image converter and resizer. Are you a website designer? Are you tired of studying too complex image processing software? Now, 'Electronic sounds' covers a wide range: Garageband comes with five synths: the ARP 2600, the Minimoog, the Waldorf Wave, the Nord Lead 1 and the Yamaha DX7, all of which can programmed. It works exactly like the sustain pedal on my piano though it is a bit. Whether they are suitable for your needs is entirely subjective. I am using this with Garageband and Mainstage 3 with my M-Audio Oxygen 66 keyboard. Prices can vary wildly and some are hundreds of dollars. There are many third-party sample libraries that include strings (these may require the use of a VST/AU plug-in such as Kontakt). It has to be said that the quality of most of the orchestral samples in Garageband/Logic is not great: they were originally created at least 10 years ago when samples had to work on much less powerful CPUs and were consequently small and simple. There are other string samples in Garageband, like "Full Strings", "Strings", and "String Ensemble". Record, use loops, add effects, then mix and share your music with the world. It adds 120 patches, 50 kits and 2,800 loops from the likes of Mark Ronson, TRAKGIRL, Boys Noize, Mark Lettieri, Soulection, Take A Daytrip and more. It is a single player, rather than a 'section' of several players. GarageBand is a fully equipped music creation studio inside your Mac with a complete sound library that includes instruments, presets for guitar and voice, and an incredible selection of session drummers and percussionists. MainStage 3.6, which is concerned mostly with live performance, adds a number of stability improvements, bug fixes and an expanded Sound Library offering music-makers more options. It comes with several articulations: pizzicato, up and down bows, tremolo, trills and legato. MainStage 3.6 includes the same Mac Studio support, and also offers a new design and an expanded Sound Library. You can use all your favourite instrument and effect plug-ins from Logic Pro. MainStage has something for every kind of performer. And give your audience a show they’ll never forget. There is a cello in Garageband (or at least, it's shown in MainStage and Logic under a "Garageband" sample heading). Transform your keyboard, guitar or vocal performance with an enormous collection of plug-ins and sounds. How MainStage passes through MIDI messages Export and import layouts Change the aspect ratio of a layout Perform live with MainStage. The purchase of MainStage gives you access to the same sample libraries as are found in Logic, which are a superset of those in Garageband. Let’s understand it with the above example. In the JS port of these we initially kept these orderings the same to stick closely to the Python functions, but in practice, it turns out to be more pragmatic to flip them, so the function gets to be the second param. Print(*(itertools.zip_longest(seq1, seq2,fillvalue = "empty")))Īs I have already explained that fillvalue is an optional parameter with a default value is None. In Python, many of the itertools take a function as an argument. You will understand more when you see the full code together for this zip_longest() function. Python 3 does not need this any more as the built-in zip is already an iterator. In Python 3 there is no itertools.izip () as the zip () builtin behaves similarly. Here “empty” will be an alternative sequence value after the second sequence length gets over. print(*(itertools.zip_longest(seq1, seq2,fillvalue = "empty"))) The module standardizes a core set of fast, memory efficient tools that are useful by themselves or in combination. Each has been recast in a form suitable for Python. This module implements a number of iterator building blocks inspired by constructs from APL, Haskell, and SML. Step3:Ībove all and Most importantly, Call the Python zip_longest() function. Functions creating iterators for efficient looping. As you can see here both are of different lengths. We have defined two lists which are a sequence of some numeric value. It goes through each element of each passed iterable, then returns a single iterator with the contents of all passed iterators. chain() The chain() function takes several iterators as arguments. Here the iterables are of different lengths. Itertools is a Python module of functions that return generators, which are objects that only function when iterated over. Secondly, Define the sequence/ iterable objects. Actually the above function is the member of itertools package in python. Step 1 :įirstly, Import the itertools module. In Python 3, izip() and imap() have been removed from itertools and replaced the zip() and map() built-ins. Now, let us understand this above function. To return an iterator, the izip() and imap() functions of itertools must be used. Not only list but tuple, string, dict are iterable python objects. Here this list_example is an iterator because we can iterator over its element. I am assuming that you all understand the list in python. Iterators are python objects of the sequence data. Step By Step Implementation of Python zip_longest() function :īefore we start the step by step implementation for zip_longest() function. In Python 3, izip() and imap() have been removed from itertools and. In case the user does not define the fillvalue parameter, zip_longest() function fills None as the default value. To return an iterator, the izip() and imap() functions of itertools must be used. In this situation, the python zip_longest() function can fill up the position of empty iterable with some user-defined values. We iterate them together obviously one iterator must end up with another iterator. Suppose we have two iterators of different lengths. Are you looking for the complete information on Python zip_longest() function? In this article, we will see how can use Python zip_longest() function with some examples. Package plan for installation in environment C:\Users\xyz\Miniconda3: pip has its issues.Ĭonda, install conda from : command prompt C:\Users\xyz>conda install -c anaconda scipy=0.18.1 I prefer to go the faster route of using Conda. Rather than going the harder route of downloading specific packages. In the output you will observe cp35 is there, so download cp35 for numpy as well as scipy.Further edits are most welcome. scipy-0.15.1-cp33-none-win_ is not supported wheel on this platformįor the above error: start Python and type : import pip.You should consider upgrading via the 'python -m pip install -upgrade pip' command You are using pip version 7.1.0, however version 8.1.2 is available.To check which version is supported by your pip, go to point No 2 below. pip install FileName.whlīe aware of the file name (check the version number).Įx :scipy-0.18.1-cp35-cp35m-win_amd64.whl If below command is not working then proceed further pip install scipyįirst install numpy and scipy. If you are totally new to python read step by step or go directly to last step.įollow the below method to install scipy 0.18.1 on Windows 64-bit, Python 64-bit. InstallationError: Command /Users/administrator/dev/KaggleAux/env/bin/python2.7 -c "import setuptools, tokenize _file_='/Users/administrator/dev/KaggleAux/env/build/scipy/setup.py' exec(compile(getattr(tokenize, 'open', open)(_file_).read().replace('\r\n', '\n'), _file_, 'exec'))" install -record /var/folders/zl/7698ng4d4nxd49q1845jd9340000gn/T/pip-eO8gua-record/install-record.txt -single-version-externally-managed -compile -install-headers /Users/administrator/dev/KaggleAux/env/bin/./include/site/python2.7 failed with error code 1 in /Users/administrator/dev/KaggleAux/env/build/scipy Requirement.install(install_options, global_options, *args, **kwargs)įile "/Users/administrator/dev/KaggleAux/env/lib/python2.7/site-packages/pip/req.py", line 706, in installĬwd=self.source_dir, filter_stdout=self._filter_install, show_stdout=False)įile "/Users/administrator/dev/KaggleAux/env/lib/python2.7/site-packages/pip/util.py", line 697, in call_subprocess Requirement_set.install(install_options, global_options, root=options.root_path)įile "/Users/administrator/dev/KaggleAux/env/lib/python2.7/site-packages/pip/req.py", line 1435, in install Removing temporary dir /Users/administrator/dev/KaggleAux/env/build.įile "/Users/administrator/dev/KaggleAux/env/lib/python2.7/site-packages/pip/basecommand.py", line 122, in mainįile "/Users/administrator/dev/KaggleAux/env/lib/python2.7/site-packages/pip/commands/install.py", line 283, in run How can I get scipy to build successfully? This may be a new issue with OSX Yosemite since I just upgraded and haven't had issues installing scipy before. Storing debug log for failure in /Users/administrator/.pip/pip.log Pip fails to build scipy and throws the following error: Cleaning up.Ĭommand /Users/administrator/dev/KaggleAux/env/bin/python2.7 -c "import setuptools, tokenize _file_='/Users/administrator/dev/KaggleAux/env/build/scipy/setup.py' exec(compile(getattr(tokenize, 'open', open)(_file_).read().replace('\r\n', '\n'), _file_, 'exec'))" install -record /var/folders/zl/7698ng4d4nxd49q1845jd9340000gn/T/pip-eO8gua-record/install-record.txt -single-version-externally-managed -compile -install-headers /Users/administrator/dev/KaggleAux/env/bin/./include/site/python2.7 failed with error code 1 in /Users/administrator/dev/KaggleAux/env/build/scipy Spatial analysis and data science: data wrangling and engineering, working with spatial data as pandas dataframes, spatial analysis, mapping and visualization, machine learning and deep learningįor more details on what you can do with the API and a deep dive into the modules, please see the Overview of the ArcGIS API for Python.When installing scipy through pip with : pip install scipy.Content management: authoring and publishing content (layers, web maps, services), cloning and moving content within and between organizations, editing and updating layers and services.GIS organization administration: management of users, groups, items, and servers, customizing the look and feel of your ArcGIS Enterprise or ArcGIS Online organization.The ArcGIS API for Python is a powerful, modern Pythonic library that supports the latest releases of ArcGIS Enterprise and ArcGIS Online and provides a consistent programmatic experience for scripting and automating across the ArcGIS product suite. Patient reminder cards about the risk of osteonecrosis of the jaw are being introduced for intravenous bisphosphonates and denosumab. Bisphosphonate-associated osteonecrosis of the external auditory canal. Bisphosphonate-induced osteonecrosis of the external auditory canal: a case report. Osteonecrosis of the external auditory canal associated with oral bisphosphonate therapy: case report and literature review. Bisphosphonate-associated osteonecrosis of the auditory canal. Bisphosphonate-induced osteonecrosis of the external ear canal: a retrospective study. Bilateral bisphosphonate-associated osteonecrosis of the external ear canal: a rare case. Summaries of Product Characteristics can be found here on the MHRA website or on the website of the European Medicines Agency, depending whether the medicine has a national or European licence, respectively. However, this possible risk is being kept under close review, given that denosumab is known to be associated with osteonecrosis of the jaw.Īrticle citation: Drug Safety Update volume 9 issue 5 December 2015: 3. The available data do not support a causal relation between osteonecrosis of the external auditory canal and denosumab. Evidence for an association with denosumab treatment The number of cases of osteonecrosis of the external auditory canal reported in association with bisphosphonates is low compared with the number of cases reported of bisphosphonate-related osteonecrosis of the jaw, a well-established side effect of bisphosphonates. Bilateral osteonecrosis of the external ear canal was reported in some patients, as was osteonecrosis of the jaw. Most cases were associated with long-term bisphosphonate therapy for 2 years or longer, and most cases had possible risk factors including: steroid use chemotherapy and possible local risk factors such as infection, an ear operation, or cotton-bud use. Cases have been reported with use of both intravenous or oral bisphosphonates for both cancer-related or osteoporosis indications there is currently insufficient evidence to determine whether there is any increased risk with higher doses used for cancer-related conditions. Product information is being updated to include advice for healthcare professionals and patients.Ī total of 29 reports indicative of osteonecrosis of the external auditory canal in association with bisphosphonates have been identified worldwide, including 11 cases reported in the clinical literature. Evidence for an association with bisphosphonate treatmentĮvidence from the clinical literature and from cases reported to medicines regulators, including one report received via the UK Yellow Card scheme, supports a causal association between bisphosphonates and osteonecrosis of the external auditory canal. Osteonecrosis of the external auditory canalīenign idiopathic osteonecrosis of the external auditory canal is a rare condition that can occur in the absence of antiresorptive therapy and is sometimes associated with local trauma. The following bisphosphonates are available in the UK: Individual bisphosphonates have different indications (see individual Summaries of Product Characteristics ). Report any cases of osteonecrosis of the external auditory canal suspected to be associated with bisphosphonates or any other medicines, including denosumab, on a Yellow Cardīisphosphonates are used to treat osteoporosis, Paget’s disease, and as part of some cancer regimens, particularly for metastatic bone cancer and multiple myeloma.Patients should be advised to report any ear pain, discharge from the ear, or an ear infection during bisphosphonate treatment. Possible risk factors include steroid use and chemotherapy, with or without local risk factors such as infection or trauma.The possibility of osteonecrosis of the external auditory canal should be considered in patients receiving bisphosphonates who present with ear symptoms, including chronic ear infections, or in patients with suspected cholesteatoma. |
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